SV40 T Ag 抗体 (Pab 108)
SV40 T Ag Antibody (Pab 108)
详细描述:
Simian virus SV40 has provided an important model for studies of cellular mechanisms involved in a malignant transformation. The major SV40 translational products include the large T antigen and the small T antigen, both of which are encoded by the early region of the SV40 viral ge-nome. The large T antigen complexes with the p53 suppressor gene, resulting in its functional inactivation, thus promoting cell transformation. In addition, SV40 large T antigen binds DNA polymerase and the transcription factor AP-2. It also forms complexes with a second tumor supressor gene-encoded protein, Rb 105. Binding of SV40 T antigen is specific for the “pocket” domain of Rb p105, which is also the binding site for the E2F cellular transcription factor.
应用范围:WB, IP, IF, IHC(P);反应种属:SV40 ;Isotype:mouse monoclonalIgG2a κ;标记:未标记。
货号 |
名称 |
单位 |
购买 |
sc-148 |
SV40 T Ag 抗体 (Pab 108) |
200 µg/ml |
咨询客服 |