详细描述：
β-catenin Antibody (E-5) is a high quality monoclonal beta-catenin antibody (also designated beta-Catenin or CTNNB1 antibody) suitable for the detection of the beta-catenin protein of mouse, rat and human origin. β-catenin Antibody (E-5) is available as both the non-conjugated anti-beta-catenin antibody form, as well as multiple conjugated forms of anti-beta-catenin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The catenins, α, β and γ, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPµ associates with catenin/cadherin complexes and may regulate complex signaling.

应用范围：WB, IP, IF, IHC(P), ELISA；反应种属：mouse, rat,human ；Isotype：mouse monoclonal IgG1 κ；标记：未标记。

详细描述：
α-E-Catenin抗体检测内源性alpha-E catenin蛋白的水平，抗体可能与神经alpha-N- catenin交叉反应，在一些细胞裂解物种，抗体可能与一个50kDa的未知条带交叉反应。多克隆抗体由合成的 肽段免疫动物产生，该肽段与人α-E-Catenin的羧基末端序列对应。抗体由蛋白A和肽段亲和层析纯化得到。α-E-Catenin Antibody detects endogenous levels of alpha-E catenin protein. The antibody may cross-react with neuronal α-N-catenin. In some cell lysates, the antibody may cross-react with a 50 kDa band of unknown origin.Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal sequence of human α-E-Catenin. Antibodies are purified using protein A and peptide affinity chromatography.

应用范围：W IF-IC； 反应种属：Human,Mouse,Rat； 标记：无标记。