标签归档：霉素

盐霉素-BSA 偶联物 货号50568-AAT Bioquest荧光染料

发表于由

上海金畔生物科技有限公司代理AAT Bioquest荧光染料全线产品，欢迎访问AAT Bioquest荧光染料官网了解更多信息。

盐霉素-BSA 偶联物

盐霉素-BSA 偶联物

盐霉素-BSA 偶联物 货号50568 货号 50568 存储条件
规格 1 mg 价格 5940
Ex (nm) Em (nm)
分子量 N/A 溶剂
产品详细介绍

简要概述

产品基本信息

货号：50568

产品名称：盐霉素-BSA 偶联物

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

 

产品物理化学光谱特性

分子量：N/A

外观：固体

溶剂：水

 

产品介绍

盐霉素是一种由白色链霉菌生产的聚醚单羧酸。它用于预防由 E. necatrix、E.tenella、E. acervulina、E. brunette、E. maxima 和 E. mivati 引起的家禽球虫病。盐霉素对某些革兰氏阳性菌有活性，而肠杆菌科细菌则有抗药性。盐霉素对产气荚膜梭菌也有抑制作用，因此使用盐霉素可降低肉鸡坏死性肠炎的发生率。盐霉素被认为是标记残留物，皮肤/脂肪是目标组织。与其他聚醚离子载体相比，盐霉素在鸡蛋中产生的残留水平相对较低。盐霉素-BSA 偶联物用于开发和筛选盐霉素抗体。它也是通过 ELISA 定量盐霉素的极佳试剂。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的盐霉素-BSA 偶联物。 

 

参考文献

Simultaneous immunodetection of ionophore antibiotics, salinomycin and narasin, in poultry products and milk.
Authors: Burkin, Maksim A and Galvidis, Inna A
Journal: Analytical methods : advancing methods and applications (2021): 1550-1558
Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer.
Authors: Talkowski, Karol and Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2021): 317-326
Evaluation of Variances in VEGF-A-D and VEGFR-1-3 Expression in the Ishikawa Endometrial Cancer Cell Line Treated with Salinomycin and An-ti-Angiogenic/Lymphangiogenic Effect.
Authors: Kras, Piotr and Talkowski, Karol and Grabarek, Beniamin Oskar and Dziobek, Nina and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2020)
Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line.
Authors: Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Wierzbik-Strońska, Magdalena and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2020): 1269-1277
Combination of salinomycin and radiation effectively eliminates head and neck squamous cell carcinoma cells in vitro.
Authors: Gehrke, Thomas and Hackenberg, Stephan and Polat, Bülent and Wohlleben, Gisela and Hagen, Rudolf and Kleinsasser, Norbert and Scherzad, Agmal
Journal: Oncology reports (2018): 1991-1998
Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.
Authors: Chung, Seyung S and Adekoya, Debbie and Enenmoh, Ikechukwu and Clarke, Orette and Wang, Piwen and Sarkyssian, Marianna and Wu, Yong and Vadgama, Jaydutt V
Journal: Anticancer research (2017): 445-453
Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes.
Authors: Scherzad, Agmal and Hackenberg, Stephan and Schramm, Carolin and Froelich, Katrin and Ginzkey, Christian and Hagen, Rudolf and Kleinsasser, Norbert
Journal: Toxicology in vitro : an international journal published in association with BIBRA (2015): 813-8
Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells.
Authors: Wang, Dan and Upadhyaya, Bijaya and Liu, Yi and Knudsen, David and Dey, Moul
Journal: BMC cancer (2014): 591
Sample treatment platform using nanoparticles to determine salinomycin in flesh and meat.
Authors: Park, Jihyun and Lim, H B
Journal: Food chemistry (2014): 112-7
Biodegradation of polyether algal toxins–isolation of potential marine bacteria.
Authors: Shetty, Kateel G and Huntzicker, Jacqueline V and Rein, Kathleen S and Jayachandran, Krish
Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering (2010): 1850-7

说明书
盐霉素-BSA 偶联物.pdf

盐霉素-KLH 偶联物 货号50569-AAT Bioquest荧光染料

发表于由

上海金畔生物科技有限公司代理AAT Bioquest荧光染料全线产品，欢迎访问AAT Bioquest荧光染料官网了解更多信息。

盐霉素-KLH 偶联物

盐霉素-KLH 偶联物

盐霉素-KLH 偶联物 货号50569 货号 50569 存储条件
规格 1 mg 价格 5940
Ex (nm) Em (nm)
分子量 N/A 溶剂
产品详细介绍

简要概述

产品基本信息

货号：50569

产品名称：盐霉素-KLH 偶联物

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

 

产品物理化学光谱特性

分子量：N/A

外观：固体

溶剂：水

 

产品介绍

盐霉素是一种由白色链霉菌生产的聚醚单羧酸。它用于预防由 E. necatrix、E.tenella、E. acervulina、E. brunette、E. maxima 和 E. mivati 引起的家禽球虫病。盐霉素对某些革兰氏阳性菌有活性，而肠杆菌科细菌则有抗药性。盐霉素对产气荚膜梭菌也有抑制作用，因此使用盐霉素可降低肉鸡坏死性肠炎的发生率。盐霉素被认为是标记残留物，皮肤/脂肪是目标组织。与其他聚醚离子载体相比，盐霉素在鸡蛋中产生的残留水平相对较低。盐霉素-KLH 偶联物用于开发和筛选盐霉素抗体。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的盐霉素-KLH 偶联物。 

 

参考文献

Simultaneous immunodetection of ionophore antibiotics, salinomycin and narasin, in poultry products and milk.
Authors: Burkin, Maksim A and Galvidis, Inna A
Journal: Analytical methods : advancing methods and applications (2021): 1550-1558
Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer.
Authors: Talkowski, Karol and Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2021): 317-326
Evaluation of Variances in VEGF-A-D and VEGFR-1-3 Expression in the Ishikawa Endometrial Cancer Cell Line Treated with Salinomycin and An-ti-Angiogenic/Lymphangiogenic Effect.
Authors: Kras, Piotr and Talkowski, Karol and Grabarek, Beniamin Oskar and Dziobek, Nina and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2020)
Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line.
Authors: Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Wierzbik-Strońska, Magdalena and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2020): 1269-1277
Combination of salinomycin and radiation effectively eliminates head and neck squamous cell carcinoma cells in vitro.
Authors: Gehrke, Thomas and Hackenberg, Stephan and Polat, Bülent and Wohlleben, Gisela and Hagen, Rudolf and Kleinsasser, Norbert and Scherzad, Agmal
Journal: Oncology reports (2018): 1991-1998
Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.
Authors: Chung, Seyung S and Adekoya, Debbie and Enenmoh, Ikechukwu and Clarke, Orette and Wang, Piwen and Sarkyssian, Marianna and Wu, Yong and Vadgama, Jaydutt V
Journal: Anticancer research (2017): 445-453
Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes.
Authors: Scherzad, Agmal and Hackenberg, Stephan and Schramm, Carolin and Froelich, Katrin and Ginzkey, Christian and Hagen, Rudolf and Kleinsasser, Norbert
Journal: Toxicology in vitro : an international journal published in association with BIBRA (2015): 813-8
Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells.
Authors: Wang, Dan and Upadhyaya, Bijaya and Liu, Yi and Knudsen, David and Dey, Moul
Journal: BMC cancer (2014): 591
Sample treatment platform using nanoparticles to determine salinomycin in flesh and meat.
Authors: Park, Jihyun and Lim, H B
Journal: Food chemistry (2014): 112-7
Biodegradation of polyether algal toxins–isolation of potential marine bacteria.
Authors: Shetty, Kateel G and Huntzicker, Jacqueline V and Rein, Kathleen S and Jayachandran, Krish
Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering (2010): 1850-7

说明书
盐霉素-KLH 偶联物.pdf

手霉素A Manumycin A

发表于由
  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

Manumycin A手霉素A Manumycin A

手霉素A



手霉素A Manumycin A



◆产品规格/储存说明


产品详情

产品类型：生化试剂



产品特性


分子式：C31H38N2O7

分子量：550.6

CAS：52665-74-4

来源：从海洋放线菌（Streptomyces parvulus）中分离

纯度：≥98%（HPLC）

外观：黄色~棕色粉末

溶解性：溶于DMSO或甲醇，不溶于水

检测方式：经1H-NMR检测

InChi Key：TWWQHCKLTXDWBD-MVTGTTCWSA-N

Smiles：

CCCC[C@@H](C)C=C(/C)C=C(/C)C(=O)NC1=C[C@@](O)(C=CC=CC=CC(=O)NC2=C(O)CCC2=O)[C@@H]2O[C@@H]2C1=O

 


运输/储存条件


运    输：干冰运输

短期储存温度：+4°C

长期储存温度：-20°C

建议储存条件：避光

使用事项/稳定性：自生产后在-20°C下至少可稳定储存1年；溶解后避光储存于-20°C下。


◆产品应用


●　抗生素。

●　凋亡和内质网应激介导的细胞死亡诱导剂。

●　高效、高选择性、高竞争性的细胞渗透性ras法尼基转移酶（rasfarnesyltransferase）抑制剂（IC50=30 nM ）。

●　不影响香叶基香叶基转移酶（IC50 = 180 µM）。

●　对法尼基焦磷酸具有竞争性抑制作用，而对Ras的抑制作用为非竞争性。

●　中性鞘磷脂酶抑制剂。

●　阻断大鼠心肌细胞中胰岛素诱导的MAP激酶的激活（19 μM）。

●　靶向蛋白磷酸酶1α（PP1α），并还原过氧化氢。

●　纠正强直性肌营养不良1型（DM1）中肌肉氯离子通道Clcn1的异常剪接。

●　表现出潜在的抗炎活性。

●　不可逆的人硫氧还蛋白还原酶1（TrxR-1）抑制剂（IC50=272 nM）和NADPH氧化酶活性诱导剂。其很可能充当TrxR-1 C端氧化还原中亲核

●　Sec残基的Michael受体，并产生SecTRAP（硒损害硫氧还蛋白还原酶来源凋亡蛋白），该蛋白通过氧化应激同时促进细胞凋亡、坏死，增加细

●　胞内活性氧（ROS）的产生。

●　由于外泌体释放过程中有Ras的参与，证实了手霉素A是一种外泌体分泌的抑制剂。

●　可治疗强直性肌营养不良1型（DM1）。

●　通过靶向蛋白磷酸酶1α 介导淋巴瘤细胞凋亡。

◆产品列表

产品编号

产品名称

包装

BVT-0091-M001

Manumycin A
手霉素A

1 mg

BVT-0091-M005

5 mg

BVT-0091-M010

10 mg

相关产品


产品编号

产品名称

包装

BVT-0414

Dihydromanumycin A
二氢手霉素 A

1 mg

BVT-0264

Manumycin B
手霉素B

1 mg

BVT-0158

Deoxymanumycin A
法尼基转移酶

1 mg

BVT-0139

Rebeccamycin
瑞拜克

250 μg

1 mg

BVT-0100

Chrysomycin B
金黄霉素B

250 μg

1 mg

BVT-0099

Chrysomycin A
金黄霉素A

250 μg

1 mg

BVT-0095

Pyrrolcarbonyltaloside

1 mg

BVT-0070

Mutolide

1 mg

※ 本页面产品仅供研究用，研究以外不可使用。


参考文献


1.

Identification of Rasfarnesyltransferase inhibitors by microbial screening: M. Hara et al.; PNAS 90, 2281 (1993)

2.

Inhibitors of Rasfarnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review)

3.

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994)

4.

Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes: Y. Zou et al.; J. Biol. Chem. 271, 33592 (1996)

5.

Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000)

6.

Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001)

7.

Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005)

8.

Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006)

9.

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics: G. Porcu, et al.; Mol. Cancer 9:197 (2010)

10.

Targeting farnesyl-transferase as a novel therapeutcstrategy for mevalonate kinase defiency: In vitro and in vivo approaches: L. De Leo, et al.; Pharmacol. Res. 61, 506 (2010)

11.

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice: K. Oana, et al.; Sci. Rep. 3, 2142 (2013)

12.

Manumycin induces apoptosis in prostate cancer cells: J.G. Li, et al., Onco Targets Ther. 7, 771 (2014)

13.

The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis. G.B. Carey, et al.; Exp. Cell. Res. 332, 136 (2015)

14.

Manumycin A from a new streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma: C.J. Jae, et al.; Int. J. Oncol. 47, 1954 (2015)

15.

Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes: E. Cecrdlova, et al.; Immunol. Lett. 169, 8 (2016)

16.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells: A. Datta, et al.; Cancer Lett. 408, 73 (2017)

17.

Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1): A. Tuladhar & K.S. Rein; ACS Med. Chem. Lett. 9, 318 (2018)

18.

The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways: A. Matoba, et al.; Am. J. Physiol. 314, 333 (2018)

19.

Effectors of thioredoxin reductase: Brevetoxins and manumycin-A: A. Tuladhar, et al.; Comp. Biochem. Physiol. C Toxicol. Pharmacol. 217, 76 (2019)

20.

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors: M. Catalano & L. O'Driscoll; J. Etracell. Vesicles 9, 1703244 (2020)

21.

Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells: M. Macejova, et al.; Toxicol. Vitro 66, 104860 (2020)

产品编号 产品名称 产品规格 产品等级

Manumycin A 手霉素A 品牌：Bioviotica

发表于由

品牌：Bioviotica
CAS No.：52665-74-4
储存条件：-20°C
纯度：>98% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BVT-0091-M010

 – 10 mg –

Manumycin A 手霉素A 品牌：Bioviotica

 – –


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产品描述相关资料下载相关产品浏览记录 可作为外泌体释放抑制剂。