应用：

　流式细胞仪、荧光显微镜、荧光检测。

　使用事项/稳定性：

　Annexin V-EnzoGold 和结合缓冲液应在４°C储存。
　其他全部试剂应在-20°C储存。
　重组诱导剂（星形孢菌素）应在-20°C下储存。具体请参阅说明书。

　储存条件：

　避光。

　运输：

　蓝冰运输。

　短期储存温度：

　４°C

　试剂盒构成：

　凋亡检测试剂 (Annexin   V-EnzoGold)
　坏死检测试剂
　凋亡诱导剂（Staurosporine）
　结合缓冲液（10X）

　技术信息/产品说明：

　应用说明：
　Image-Based Analysis of a Human Neurosphere Stem Cell Model for the Evaluation of Potential　

　Neurotoxicants
　引用样本：
　For an overview on cited samples please click here.

　监管状况：

　RUO-仅供研究用

产品编号

产品名称

应用

规格

BML-AP502-0025

3-Methyladenine

3-甲基腺嘌呤，PI3激酶抑制剂

25 mg

BML-CM110-0100

Bafilomycin A1

巴伐洛霉素，ATPase抑制剂

100 μg

产品编号

产品名称

应用

规格

产品编号

产品名称

BML-PE180-0001

Thapsigargin

毒胡萝卜素，ATPase抑制剂

1 mg

BML-PE180-0001

Thapsigargin

BML-CC104-0010

Tunicamycin

衣霉素，GlcNAc磷酸转移酶抑制剂

10 mg

BML-CC104-0010

Tunicamycin

ALX-550-084-G005

Carbamazepine

卡马西平，镇痉剂和止痛剂

5 g

ALX-550-084-G005

Carbamazepine

BML-SL100-0005

C2 Ceramide

C2-神经酰胺，细胞渗透性神经酰胺类似

5 mg

BML-SL100-0005

C2 Ceramide

BML-A275-0005

Rapamycin

雷帕霉素，免疫抑制剂

5 mg

BML-A275-0005

Rapamycin

BML-CA409-0050

Xestospongin C

IP3受体抑制剂

50 μg

BML-CA409-0050

Xestospongin C

产品编号

产品名称

应用

规格

BML-AP502-0025

3-Methyladenine

3-甲基腺嘌呤，PI3激酶抑制剂

25 mg

BML-CM110-0100

Bafilomycin A1

巴伐洛霉素，ATPase抑制剂

100 μg

 1.

Inhibitory role of TRIP-Br1/XIAP in necroptosis under nutrient/serum starvation: Z. Sandag, et al.; Mol. Cells 43, 236 (2020), 摘要;  全文

 2.

Inhibitory role of AMP‑activated protein kinase in necroptosis of HCT116 colon cancer cells with p53 null mutation under nutrient starvation: D.T. Le, et al.; Int. J. Oncol. 54, 702 (2019), 摘要;

 3.

Injectable and Quadruple-Functional Hydrogel as an Alternative to Intravenous Delivery for Enhanced Tumor Targeting: Z.Q. Zhang, et al.; ACS Appl. Mater. Interfaces 11, 34634 (2019), 摘要;

 4.

Intrinsic antibacterial activity of nanoparticles made of β-cyclodextrins potentiates their effect as drug nanocarriers against tuberculosis: A. Machelart, et al.; ACS Nano 13, 3992 (2019), 摘要;

 5.

Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells: Y. Zhu, et al.; Oncogene 38, 5778 (2019), Application(s): Flow cytometry using MCF-7 cells, 摘要;

  6.

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation: T. Li, et al.; Protein Cell 10, 583 (2019), Application(s): Flow cytometry using H1299 and HepG2 cells, 摘要;

 7.

Tamoxifen acts on Trypanosoma cruzi sphingolipid pathway triggering an apoptotic death process: M. Landoni, et al.; Biochem. Biophys. Res. Commun. 516, 934 (2019), 摘要;

 8.

Anti-leukemic efficacy of BET inhibitor in a preclinical mouse model of MLL-AF4+ infant ALL: M. Bardini, et al.; Mol. Cancer Ther. 17, 1705 (2018), 摘要;

 9.

Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5: C. Angelucci, et al.; Oncotarget. 9, 24364 (2018), Application(s): Fluorescent microscopy with MCF-7 cells, 摘要; 全文

10.

Preclinical efficacy and safety of CD19CAR cytokine-induced killer cells transfected with Sleeping Beauty transposon for the treatment of acute lymphoblastic leukemia: C.F. Magnani, et al.; Hum. Gene. Ther. 29, 605 (2018), 摘要;

11.

Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage: T. Iba, et al.; Int. J. Hematol. 107, 528 (2018), 摘要;

12.

The poly (ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-κB activation: I. Faraoni, et al.; Cancer Lett. 423, 127 (2018), Application(s): Flow cytometry with primary AML cells, 摘要;

13.

Toxicity and phototoxicity in human ARPE-19 retinal pigment epithelium cells of dyes commonly used in retinal surgery: D. Awad, et al.; Eur. J. Ophthalmol. 28, 433 (2018), 摘要; 全文

14.

Cluster microRNAs miR‐194 and miR‐215 suppress the tumorigenicity of intestinal tumor organoids: T. Nakaoka, et al.; Cancer Sci. 108, 678 (2017), Application(s): Flow cytometry using organoid culture of mouse intestinal tumors, 摘要; 全文

15.

Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells: H. Ohmori, et al.; Pathobiology 84, 144 (2017), 摘要;

16.

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties: A. Dasgupta, et al.; Oncotarget. 8, 77292 (2017), Application(s): Flow cytometry with A673 cells, 摘要; 全文

17.

Multiple hyperthermia-mediated release of TRAIL/SPION nanocomplex from thermosensitive polymeric hydrogels for combination cancer therapy: Z.Q. Zhang, et al.; Biomaterials. 132, 16 (2017), Application(s): Confocal microscopy with PC3 and U-87 MG cells, 摘要;

18.

Pro-metastatic intracellular signaling of the elaidic trans fatty acid: K. Fujii, et al.; Int. J. Oncol. 50, 85 (2017), 摘要;

19.

Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis: M. Yamane, et al.; Biochem. Biophys. Rep. 11, 174 (2017), Application(s): Confocal microscopy with A549 cells, 摘要; 全文

20.

Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform: C.F. Magnani, et al.; Oncotarget 7, 51581 (2016), Application(s): Flow cytometry using KG-1, REH, Nalm-6, and THP-1 cells, 摘要; 全文

21.

Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts: N. Sumudu, et al.; Eur. J. Pharmacol. 781, 128 (2016), 摘要;

22.

Phlorofucofuroeckol Improves Glutamate-Induced Neurotoxicity through Modulation of Oxidative Stress-Mediated Mitochondrial Dysfunction in PC12 Cells: J.J. Kim, et al.; PLoS One 11, e0163433 (2016), 摘要; 全文

23.

PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis: A. Nguyen, et al.; J. Clin. Invest. 126, 681 (2016), Application(s): Assessed Apoptosis, Flow cytometry, 摘要; 全文

24.

Protective effects of β‐casofensin, a bioactive peptide from bovine β‐casein, against indomethacin‐induced intestinal lesions in rats: C. Bessette, et al.; Mol. Nutr. Food Res. 60, 823 (2016), 摘要;

25.

BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib: I. Faraoni, et al.; Biochim. Biophys. Acta 1852, 462 (2015), Application(s): Flow cytometry using primary AML cells, 摘要;

26.

Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex: V. Marfil, et al.; Oncogene 34, 3011 (2015), Application(s): Flow cytometry using HO15.19 and TGR-1 cells, 摘要;

27.

common set of proteins modulated in Chikungunya virus infection: R. Abraham, et al.; J. Proteomics. 120, 126 (2015), Application(s): Flow cytometry using HEK293 cells, 摘要;

28.

Identification of novel osteogenic compounds by an ex-vivo sp7: luciferase zebrafish scale assay: E. de Vrieze, et al.; Blood 74, 106 (2015), Application(s): Fluorescence microscopy using fish scales, 摘要;

29.

Impaired oxidative phosphorylation regulates necroptosis in human lung epithelial cells: M.J. Koo, et al.; Biochem. Biophys. Res. Commun. 464, 875 (2015), Application(s): Apoptosis/necrosis assay, 摘要;

30.

Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection: J.D. Londino, et al.; FASEB J. 29, 2712 (2015), Application(s): Flow cytometry using HEK293 cells, 摘要; 全文

31.

Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress: K. Sakitani, et al.; BMC Cancer 15, 795 (2015), Application(s): Flow cytometric analysis of apoptosis, 摘要; 全文

32.

N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting: P.H. Lin, et al.; J. Biomed. Sci. 22, 44 (2015), Application(s): Fluorescence microscopy using HaCaT and HEK293 cells, 摘要; 全文

33.

Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells.: K.S. Bhullar, et al. ; Chem. Biol. Interact. 242, 107 (2015), Application(s): Fluorescence microscopy, 摘要;

34.

NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival: J.M. Calandria, et al.; Cell Death Differ. 22, 1363 (2015), Application(s): Assay, 摘要;

35.

ROS-induced oxidative stress and apoptosis-like event directly affect the cell viability of cryopreserved embryogenic callus in Agapanthus praecox: D. Zhang, et al.; Plant Cell Rep. 34, 1499 (2015), 摘要;

36.

The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis: C.C. Hsiao, et al.; Int. J. Biochem. Cell. Biol. 65, 197 (2015), Application(s): Flow cytometry using HT1080 cells, 摘要;

37.

The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage: T. Iba, et al.; Thromb. Res 135, 963 (2015), Application(s): Fluorescence Microscopy using leukocytes, 摘要;

38.

Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma: M. Nomura, et al.; Cancer Res. 74, 1056 (2014), 摘要;

39.

Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus: S.V. Nair, et al.; Biomed. Res. Int. 2014, Article ID 637098 (2014), Application(s): Measurement by flow cytometry, 摘要; 全文

40.

Combination of antithrombin and recombinant thrombomodulin modulates neutrophil cell-death and decreases circulating DAMPs levels in endotoxemic rats: T. Iba, et al.; Throm. Res. 134, 169 (2014), Application(s): Detection Kit using live cells, 摘要;

41.

Fatty acid esters of ohloridzin induce apoptosis of human liver cancer cells through altered gene expression: S.V. Nair, et al.; PLoS One 9, e107149 (2014), Application(s): Fluorescence microscopy of HepG2 cells, 摘要; 全文

42.

Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells: S. Sudan, et al.; Nutr. Cancer 66, 1237 (2014), 摘要;

43.

Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells: S. Sudan, et al.; Anticancer Res. 34, 1691 (2014), 摘要;

44.

A light-activated NO donor attenuates anchorage independent growth of cancer cells: Important role of a cross talk between NO and other reactive oxygen species: S. Sen, et al.; Arch. Biochem. Biophys. 540, 33 (2013), Application(s): Detection Kit using live cells, 摘要;

45.

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks: L.M. Holdt, et al.; PLoS Genet. 9, e1003588 (2013), Application(s): Detection Kit using live cells, 摘要; 全文

46.

Analysis of protein translocation into the endoplasmic reticulum of human cells: J. Dudek, et al.; Methods Mol. Biol. 1033, 285 (2013), 摘要;

47.

Characterizing virulence-specific perturbations in the mitochondrial function of macrophages infected with Mycobacterium tuberculosis: S. Jamwal, et al.; Sci. Rep. 3, 1328 (2013), 摘要; 全文

48.

Evaluation of anticancer effects and enhanced doxorubicin cytotoxicity of xanthine derivatives using canine hemangiosarcoma cell lines: T. Motegi, et al.; Res. Vet. Sci. 95, 600 (2013), Application(s): Fluorescence microscopy using canine HAS cells, 摘要;

49.

Genista sessilifolia DC. extracts induce apoptosis across a range of cancer cell lines: P. Bontempo, et al.; Cell Prolif. 46, 183 (2013), Application(s): Detection Kit using live cells, 摘要;

50.

High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy: Y. Luo, et al.; Eur. J. Cancer. 49, 741 (2013), Application(s): Fluorescence microscopy using CT26 cells, 摘要;

51.

Influence of gefitinib and erlotinib on apoptosis and c-MYC expression in H23 lung cancer cells: M. Suenaga, et al.; Anticancer Res. 33, 1547 (2013), 摘要;

52.

Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells: V. Marin, et al.; Hum. Gene Ther. Methods 23, 376 (2012), Application(s): Flow cytometry using EBV-CTL and 293 T cells, 摘要; 全文

53.

Maintenance of higher H2O2 levels, and its mechanism of action to induce growth in breast cancer cells: Important roles of bioactive catalase and PP2A: S. Sen, et al.; Free Radic. Biol. Med. 53, 1541 (2012), Application(s): Detection Kit using live cells, 摘要;

54.

Mesenchymal stem cells from Shwachman–Diamond syndrome patients display normal functions and do not contribute to hematological defects: V. André, et al.; Blood Cancer J. 2, e94 (2012), Application(s): Flow cytometry using human neutrophils, 摘要; 全文

55.

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria: H. Yamada, et al.; Free Radic. Biol. Med. 52, 1716 (2012), Application(s): Fluorescence microscopy using mouse hepatocytes, 摘要;

56.

Molecular mechanism of interleukin-2-induced mucosal homeostasis : J. Mishra, et al.; Am. J. Physiol. Cell Physiol. 302, C735 (2012), Application(s): Detection Kit using live cells, 摘要; 全文

57.

Serratia marcescens induces apoptotic cell death in host immune cells via a lipopolysaccharide- and flagella-dependent mechanism: K. Ishii, et al.; J. Biol. Chem. 287, 36582 (2012), Application(s): Apoptosis detected in Silkworm larvae, 摘要;

58.

Serratia marcescens Induces Apoptotic Cell Death in Host Immune Cells via a Lipopolysaccharide- and Flagella-dependent Mechanism: K. Ishii, et al.; J. Biol. Chem. 287, 36582 (2012), Application(s): Detection Kit using live cells, 摘要; 全文

59.

Two mutations impair the stability and function of ubiquitin-activating enzyme (E1): T. Lao, et al.; J. Cell. Physiol. 227, 1561 (2012), Application(s): Viability and induction of cell death observed by confocal microscopy, 摘要; 全文

60.

Critical roles of Cold Shock Domain Protein A as an endogenous angiogenesis inhibitor in skeletal muscle: Y. Saito, et al.; Antioxid. Redox. Signal. 15, 2109 (2011), 摘要;

61.

Cell Surface Externalization of Annexin A1 as a Failsafe Mechanism Preventing Inflammatory Responses during Secondary Necrosis: K.E. Blume, et al.; J. Immunol. 183, 8138 (2009), 摘要; 全文

62. 

Supplemental Information for: Cell Surface Externalization of Annexin A1 as a Failsafe Mechanism Preventing Inflammatory Responses during Secondary Necrosis: K.E. Blume, et al.; J. Immunol. 183, (2009), (Supplemental Information), 全文