Screen Quest 细胞趋化因子（c-x-c motif）受体4表达细胞株

	货号	38003	存储条件	在零下80度以下保存
	规格	Each	价格	0
	Ex (nm)		Em (nm)
	分子量		溶剂
	产品详细介绍

简要概述

产品基本信息

货号：38003

产品名称：Screen Quest 细胞趋化因子（c-x-c motif）受体4表达细胞株

规格：Each

产品介绍

超过60％的已知G蛋白偶联受体（GPCR）通过Gq以外的途径发出信号，导致细胞内钙的增加。随着基因组学揭示出更多的G蛋白偶联受体靶标，这种趋势持续增加。 Screen Quest 细胞趋化因子（c-c）受体2B表达细胞株能够研究通常不通过细胞内钙偶联的GPCR。 Screen Quest 细胞趋化因子（c-c）受体2B表达细胞株基于一系列G蛋白嵌合体，包括混杂的G蛋白Gα16。嵌合体由Gq蛋白复合物的α亚基组成，该复合物的5个羧基末端氨基酸已被其他G蛋白之一（Gαs，Gαi，Gαo或Gαz）取代。这些氨基酸负责受体与其G蛋白的偶联。这些嵌合体与特定的非Gq偶联受体共表达可能会在受体刺激后导致细胞内钙信号的产生。 Screen Quest 细胞趋化因子（c-c）受体2B表达细胞株是被混杂G蛋白，Gα16和趋化因子（C-C）受体2B受体（CCR2B）稳定转染的CHO-K1细胞。细胞中组成型表达的Gα16蛋白使通常通过cAMP途径发挥作用的该受体与Gq信号转导和动员的细胞内钙偶联。可以使用钙敏感性染料（例如Calbryte 520 AM，Cal-520 AM，Fluo-8 AM或Fluo-4 AM）和相应的免洗钙试剂盒检测特定配体对CCR2B的激活。该细胞系已成功用于药物发现和筛选环境中，以研究通常不通过细胞内钙偶联的GPCR。它已被FLIPR和FDSS系统有效使用。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的Screen Quest 细胞趋化因子（c-c）受体2B表达细胞株。 

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